The master’s thesis in the Department of Horticulture and Landscape Engineering – College of Agriculture – University of Kerbala discussed the effect of organic fertilization and Zytonic_F on the growth, yield and quality of two varieties of lettuce by the student Doaa Sabah Ismail Ghulam. The examination committee consisted of Professor Abbas Khudair Majul (chairman) and the membership of Assistant Professor Dr. Khaled Abdel Matar and Assistant Professor Dr. Kazem Muhammad Abdullah and Assistant Professor Dr. Muhammad Hadi Ubaid supervising the thesis and in the presence of Professor Dr. Thamer Karim Khudair, Dean of the College of Agriculture – University of Karbala, faculty professors, postgraduate students and researchers. This study aimed to know the effect of fertilizer treatments at different levels on growth and yield And the quality of two varieties of lettuce, improving the growth process and increasing the yield of the plant by using poultry manure and its interaction with Zytonic_F.