Abstract
The aim of this study was to induce balanced anesthesia characterized by good hypnosis, analgesia and reducing the side effects of the drugs at the same time, so that, the effect of ketamine administration with both morphine and aspirin was studied in 90 chicks at 10-21 day-old and compare it with the positive control group that injected with ketamine alone. Ketamine injection at 7.5, 15 and 30 mg/kg, i.m. induce loss of righting reflex (anesthesia or hypnosis) in a dose dependent manner. The onset of anesthesia is decreased and its duration and recovery from anesthesia increased significantly in the groups that administered ketamine and morphine or ketamine and aspirin or ketamine, morphine and aspirin combination when compared to ketamine alone (positive control group). The less onset of anesthesia with enhanced duration and recovery from it were significantly when ketamine injected at 15 mg/kg, i.m. mixed with morphine and aspirin at 5 and 100 mg/kg, i.m., respectively in the chicks. This combination also caused a significantly increased in the analgesic effect through its significant elevation of the voltage after injection when compared with its value before injection as well as the significant increase in the delta voltage. The result of this study recommended the induction of balanced anesthesia, which characterized by good hypnosis and analgesic efficacy through administering ketamine with central (morphine) and peripheral (aspirin) analgesics.
